Below a list of past events with contributions of the WG, with links to slidedecks and recordings (where available).

19.10.2022: ISOQoL 2022

date City Country Type
19.10.2022 Prague Czech Republic Workshop

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Rachael Lawrance: NA

20.09.2022: ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop

date City Country Type
20.09.2022 Maryland USA Contributed topic session

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Dalong Huang (FDA): Adjusting for covariates in randomized trials: draft guidance and some examples
Hong Tian (Beigene): Conditional and Unconditional Treatment Effects in Clinical Trials
Jonathan Siegel: Special interest group “Estimands in oncology”, sponsored by PSI and EFSPI
Sun et al: Estimands in Oncology: A Topical Panel Discussion

14.09.2022: EFSPI Regulatory Statistics Workshop

date City Country Type
14.09.2022 Basel Switzerland Poster

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Stefan Englert: NA

30.08.2022: 12th International Conference on Multiple Comparison Procedures

date City Country Type
30.08.2022 Bremen Germany talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Yi Liu: From Logic-respecting Efficacy Estimands to Logic-ensuring Analysis Principle in Randomized Clinical Trials with Subgroups

21.08.2022: ISCB conference

date City Country Type
21.08.2022 Newcastle UK Contributed talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Kaspar Rufibach: Follow-up time in clinical trials with a time-to-event endpoint: Redefining the question(s)

06.08.2022: Joint Statistical Meetings

date City Country Type
06.08.2022 Washington USA presentation in a TC session

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Siyoen Kil: Insights into couterfactual estimand, with application toward personalized medicine

21.07.2022: DIA annual meeting in China

date City Country Type
21.07.2022 Suzhou China Poster

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Jiawei Wei: Special interest group “Estimands in oncology”, sponsored by PSI and EFSPI

19.06.2022: ICSA (International Chinese Statistical Association) Applied Statistics Symposium

date City Country Type
19.06.2022 Gainsville Florida USA presentation

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Yue Shentu: From Logic-respecting Efficacy Estimands to Logic-ensuring Analysis Principle for Time-to-event Endpoint in Randomized Clinical Trials with Subgroups

12.06.2022: PSI annual conference

date City Country Type
12.06.2022 Gothenburg Sweden Poster and invited session

Program

Link to Program

26.05.2022: ASA Biopharmaceutical Section

date City Country Type
26.05.2022 NA NA webinar

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Yi Liu: From Logic-respecting Efficacy Estimands to Logic-ensuring Analysis Principle in Randomized Clinical Trials with Subgroups

15.05.2022: Society for Clinical Trials

date City Country Type
15.05.2022 San Diego USA Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Rachael Lawrance: The Estimand Framework from the ICH E9(R1) Statistical Principles for Clinical Trials Addendum: Current Implementation Status and Looking Forward
Godwin Yung: Answering old questions with new tools: Application of the ICH E9 addendum in oncology

26.04.2022: PSI Journal Club – Treatment Switching in Clinical Trials

date City Country Type
26.04.2022 NA UK Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Juliane Manitz: Estimands for Overall Survival in Clinical Trials with Treatment Switching in Oncology

12.10.2021: ISOQoL 2021

date City Country Type
12.10.2021 NA NA Contributed talk

Program

Link to Program

28.09.2021: DIA webinar: Estimands How and Why - A Real Life Case Study in Oncology

date City Country Type
28.09.2021 NA USA Invited training

Program

Link to Program

21.09.2021: ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop

date City Country Type
21.09.2021 NA USA Invited talks and panel discussion

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Devan Mehrotra: Estimands and Sensitivity Analyses in Clinical Trials - Strengthening Alignment with ICH E9 (R1)
Kaspar Rufibach: Session organizer

21.09.2021: ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop

date City Country Type
21.09.2021 NA USA Contributed topic session

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Juliane Manitz: Estimands for Overall Survival in Clinical Trials with Treatment Switching in Oncology
Jonathan Siegel: Rethinking Censoring and Censoring Mechanisms in Light of the Estimands Framework
Satrajit Roychoudhury: Estimand in Hematologic Oncology Trials
Yeh-Fong Chen: Discussant from FDA (no slides)
Qing Xu: Discussant from FDA (no slides)

21.09.2021: ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop

date City Country Type
21.09.2021 NA USA Contributed topic session

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Yi Liu: Correct and Logical Causal Inference in Randomized Controlled Trials with Biomarker Subgroups
Dong Xi: Conditional Estimands vs. Marginal Estimands: From Collapsibility to Logic Respect
Gene Anthony Pennello: Logical Causal Inference for the Odds Ratio and Hazard Ratio
Lei Nie: Discussant from FDA (no slides)

08.08.2021: Joint Statistical Meetings

date City Country Type
08.08.2021 NA USA Topic contributed session

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Jianchang Lin: Utilizing Surrogate Endpoints in Adaptive Designs with Delayed Treatment Effect (no slides available)
Steven Sun: Use of estimand Framework in Hematology Oncology Trials: Practical Implementation (no slides available)
Yi Liu: Logic-Respecting Efficacy Measures in the Presence of Prognostic or Predictive Biomarker Subgroups
Natalia Kan-Dobrosky: Treatment Switching and estimands for Overall Survival in Oncology Clinical Trials: Issues and Controversies

21.04.2021: Duke Industry Statistics Symposium

date City Country Type
21.04.2021 NA USA Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Natalia Kan-Dobrosky: Estimands in clinical trials with treatment switching

11.02.2021: ASA - FDA - LUNGevity symposium: Statistical considerations in Oncology clinical trials in the COVID-19 era

date City Country Type
11.02.2021 NA USA Symposium

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Evgeny Degtyarev: How can the estimand framework support decentralized trials?
Kaspar Rufibach: How can the estimand framework support decentralized trials?

09.12.2020: Deming Conference on Applied Statistics

date City Country Type
09.12.2020 NA USA Shortcourse

Program

Link to Program

27.11.2020: Working group “Pharmaceutical Industry” of the German Region of the IBS (APF)

date City Country Type
27.11.2020 NA Germany Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Hannes Buchner: Estimands update: Summary of world-wide authority interaction
Kaspar Rufibach: Estimands update: Summary of world-wide authority interaction

17.11.2020: The effective statistician podcast: A deep dive into principal stratification and causal inference

date City Country Type
17.11.2020 NA Switzerland Discussion

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Kaspar Rufibach: Link to podcast
Bjoern Bornkamp: Link to podcast

05.11.2020: Joint PSI, EFSPI & ASA BIOP Webinar: Estimands

date City Country Type
05.11.2020 NA UK / USA Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Evgeny Degtyarev: Estimand framework: What are the opportunities in oncology?

22.09.2020: ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop

date City Country Type
22.09.2020 NA USA Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Jonathan Siegel: Industry Perspective on Subsequent Therapy: An Estimands Approach

07.09.2020: Webinar of the Basel Biometrics Section: RCTs meeting causal inference: principal stratum strategy and beyond

date City Country Type
07.09.2020 NA Switzerland Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Kaspar Rufibach: Introduction
Bjoern Bornkamp: Principal Stratum Strategy: Potential Role in Drug Development

06.09.2020: GMDS & CEN IBS 2020

date City Country Type
06.09.2020 Berlin Germany Contributed talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Juliane Manitz: Estimands for Overall Survival in clinical trials with treatment switching

01.08.2020: Joint Statistical Meetings

date City Country Type
01.08.2020 Philadelphia USA Topic contributed session

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Jonathan Siegel: Estimand Framework and Its Impact on Drug Development in Oncology
Anja Schiel: Discussant (no slides)
Kunthel By: Discussant FDA (no slides)
Catherine Njue: Discussant from Health Canada (no slides)
Richard J. Cook: Discussant (no slides)

29.06.2020: Webinar of the Basel Biometrics Section: Estimands addendum is final: Anything new for oncology?

date City Country Type
29.06.2020 NA Switzerland Invited talk

Program

Link to Program

11.06.2020: PSI Conference Webinar: Impact of COVID-19 to estimands

date City Country Type
11.06.2020 NA UK Invited talk and panelist

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Kaspar Rufibach: Application of the estimand framework to assess the impact of COVID-19 on clinical trials

21.05.2020: Estimands in Oncology Virtual Panel Discussion (organized by Cytel)

date City Country Type
21.05.2020 NA USA Invited talk and panelist

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Kaspar Rufibach: Estimands in oncology
Michelle Casey: Discussant (no slides)

06.05.2020: Webinar of the Basel Biometrics Section: Impact of COVID-19 on clinical trials

date City Country Type
06.05.2020 NA Switzerland Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Evgeny Degtyarev: Short overview on COVID-19 from the Cross-Industry Oncology Estimands Working Group

20.10.2019: ISOQoL

date City Country Type
20.10.2019 San Diego USA Contributed talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Rachael Lawrance: Using PROs in clinical trials: what should I know about?

27.09.2019: ESMO

date City Country Type
27.09.2019 Barcelona Spain Poster

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Daniel George: Impact of estimand selection on adjuvant treatment outcomes in renal cell carcinoma (RCC)
Bryant Furlow: Commentary on poster

23.09.2019: EFSPI Regulatory Statistics Workshop

date City Country Type
23.09.2019 Basel Switzerland Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Evgeny Degtyarev: Estimand framework: opportunity to rethink some old (and new) problems in Oncology trials?

23.09.2019: ASA Biopharmaceutical Section Regulatory-Industry Statistics Workshop

date City Country Type
23.09.2019 Washington USA Contributed talks (including FDA discussant)

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Feng Liu: Causal Estimand and Principal Stratum, an Overview and Potential Applications in Oncology
Jiangxiu Zhou: Estimands for PFS2
Alexei C. Ionan (FDA discussant): Estimand Framework in Oncology Drug Development: Challenges and Opportunities

27.07.2019: Joint Statistical Meetings

date City Country Type
27.07.2019 Denver USA Topic contributed session

Program

Link to Program

14.07.2019: ISCB conference

date City Country Type
14.07.2019 Leuven Belgium Contributed talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Rui Tang: Estimands in the Presence of Treatment Switching

23.06.2019: DIA Annual meeting

date City Country Type
23.06.2019 San Diego USA Contributed talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Yi Liu: Estimand Framework and its Impact on Oncology Drug Development: Findings From An Industry Wide Working Group

02.06.2019: PSI annual conference

date City Country Type
02.06.2019 London UK Contributed talks

Program

Link to Program

29.05.2019: Lifetime Data Science Conference

date City Country Type
29.05.2019 Pittsburgh USA Contributed talks including EMA discussant

Program

Link to Program

18.03.2019: DAGStat

date City Country Type
18.03.2019 Munich Germany Contributed talks

Program

Link to Program

15.02.2019: HTA EFSPI SIG 1-day event

date City Country Type
15.02.2019 Berlin Germany Invited talk

Program

Link to Program

Talks and/or recording

Speaker (available slidedecks are linked)
Evgeny Degtyarev: Estimands in Oncology